Stem Cell Review: Tools for Drug Screening (EP4)
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Stem Cell Review: Tools for Drug Screening
Researchers are using stem cells as tools for disease study, drug screening, clinical trial strategy, and personalized medicine. The induced Pluripotent Stem cell (iPS) is giving us a chance to rethink the way we are developing new drugs. These iPS cells are usually created from somatic cells (such as skin), and not embryos or adult stem cells. In creating iPS from patients' diseased cells, scientists can study the disease in vitro, looking for disease phenotypes, applying microenvironmental stress, and testing new drugs. Compared to animal model testing (e.g. mice), this represents a significant breakthrough, that can be used to validate clinical development strategy and test efficacy in specific groups of patients. iPS is bringing a revolution in drug discovery methodology which is being used to bridge genetics, cell biology, and physiology.
This is the Episode 4 of the Stem Cell Review, aired on October 22nd, 2009
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Credits
In Order of Appearance:
GUESTS
Shinya Yamanaka, M.D., Ph.D. - UCSF and Kyoto University // Senior Investigator, Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology; Professor of Anatomy, University of California, San Francisco; Director, Center for iPS Cell Research and Application (CiRA), Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University; Professor, Department of Stem Cell Sciences, Institute for Frontier Medical Sciences
Gregory A. Bonfiglio - Proteus Venture Partners // Managing Partner
George Q. Daley, M.D., Ph.D. - Harvard Medical School // Samuel E. Lux, IV Chair in Hematology, Director, Stem Cell Transplantation Program, Children's Hospital Boston
John Walker - iPierian // Chief Executive Officer
Dan Marshak Ph.D. - PerkinElmer, Inc. // Chief Scientific Officer and President, Greater China
Rudolf Jaenisch, M.D., MIT // Professor of Biology, Whitehead Institute and Dept. of Biology, MIT (Massachusetts Institute of Technology)
Alan O. Trounson, Ph.D. - California Institute for Regenerative Medicine // President
IMAGES
Stem Cell Review Studio Background Pictures provided by the California Institute of Regenerative Medicine
- CIRM: Human embryonic stem cell
- CIRM: Neurons derived from human emb
- CIRM: Neuron derived from neural stem cells
- Unknown: motor neuron differentiation 1
- Unknown: motor neuron differentiation 2
A Special Thanks to:
- Ferghana Partners Group
- ISSCR / The International Society for Stem Cell Research
- Genetics Policy Institute / World Stem Cell Summit
- Hilton Hotels / The Hilton Diagonal Mar in Barcelona
MUSIC
Protest by soundroll Five Tribes by ventilo35
Last but not Least!
- Freya Alugas
- Pat Becker
- Melissa Carpenter
- Ellen Charles
- Meagan Comerford
- Karena Essex
- Elisabet Fabregas
- Mario Fante
- Rocio Fontela
- Liz Freyn
- Don Gibbons
- Raj Kaur
- Paul Laland
- Gemma Llamas
- Jillian McFady
- Mary Lou McKeone
- Didier Montarras
- Mario Oliete
- Jose Maria Ruiz
- Valerie Tucker
- Kristen April Uekermann
- Nancy Witty
- Jessica Yingling
About
Acknowledgements
